Alemtuzumab (Campath)
Anastrozole (Arimidex) |
Unknown
No dose reduction (link to the reference)
|
L-Asparaginase (Elspar)
| No dose reduction (link to the reference)
|
Bicalutamide (Casodex)
Bendamustine (Treanda)
| No dose reduction (link to the reference)
If CrCl < 40 mL/min, do not use (link to the reference)
|
Bleomycin (Blenoxane)
| If CrCl 10-50 mL/min, reduce dose by 25%
If CrCl < 10 mL/min, reduce dose by 50% (link to the reference) |
Bortezomib (Velcade) Busulfan (Myleran)
| No dose reduction (link to the reference)
No dose reduction |
Capecitabine (Xeloda)
| If CrCl 30-50 mL/min, reduce dose by 25%
If CrCl < 30 mL/min, do not use (link to the reference)
|
Carboplatin (Paraplatin)
| Dosing based on AUC (link to the reference)
|
Carmustine (BCNU)
| If CrCl < 60 mL/min, do not use |
Chlorambucil (Leukeran)
| No dose reduction |
Cisplatin (CDDP)
| If CrCl 30-60 mL/min, reduce dose by 50%
If CrCl < 30 mL/min, do not use |
| Cyclophosphamide (Cytoxan) | If CrCl 10-50 mL/min, reduce dose by 25%
If CrCl < 10 mL/min, reduce dose by 50% |
Dacarbazine (DTIC)
Dasatinib (Sprycel)
Daunorubicin (Daunomycin)
| If CrCL 10-50 mL/min, reduce dose by 25%
If CrCl < 10 mL/min, reduce dose by 50%
Unknown. < 4% excreted by kidney (link to the reference)
If Cr > 3 mg/dL, reduce dose by 50% |
| Docetaxel (Taxotere) | No dose reduction (link to the reference)
|
Doxorubicin (Adriamycin)
| No dose reduction (link to the reference)
|
Doxil (Pegylated liposomal doxorubicin)
Erlotinib (Tarceva)
| No dose reduction (link to the reference)
No dose reduction (link to the reference)
|
Etoposide (VP-16)
| If CrCl 10-50 mL/min, reduce dose by 25%
If CrCl < 10 mL/min, reduce dose by 50% |
Exemestane (Aromasin)
Fludarabine (Fludara)
Fluorouracil (5-FU)
Fulvestrant (Faslodex)
| No dose reduction (link to the reference)
If CrCl 30-70 mL/min, reduce dose by 20%
If CrCl < 30 mL/min, do not use (link to the reference)
No dose reduction (link to the article)
No dose reduction (link to the reference)
|
| Gemcitabine (Gemzar) | No dose reduction (link to the reference)
|
Goserelin (Zoladex)
| No dose reduction (link to the reference) |
| Hydroxyurea (Hydrea) | If CrCl 10-50 mL/min, reduce dose by 50%
If CrCl < 10 mL/min, reduce dose by 80% |
Idarubicin (Idamycin)
| If CrCl < 10 mL/min, reduce dose by 25% (link to the reference)
|
Imatinib (Gleevec)
| No dose reduction (link to the reference)
|
| Interferon-alpha | No dose reduction |
| Interleukin-2 | If Cr > 4-4.5 mg/dL, do not use |
Irinotecan (Camptosar, CPT-11)
Ixabepilone (Ixempra)
Lapatinib (Tykerb)
Lenalidomide (Revlimid)
Letrozole (Femara)
| No dose reduction (no dose reduction)
If CrCl > 30 mL/min, no dose reduction (link to the reference)
Not studied. Only 2% eliminated by kidneys (link to the reference)
Substantially excreted by kidney. Trials excluded patients with renal insufficiency (link to the reference)
If CrCl > 10 mL/min, no dose reduction (link to the reference)
|
Leucovorin (LV)
| No dose reduction |
Lomustine (CCNU)
Melphalan (Alkeran)
| If CrCl < 60 mL/min, do not use
PO: if CrCl < 30 mL/min, consider dose reduction (link to the reference)
IV: if BUN > 30 mg/dL, reduce dose by 50% |
Methotrexate (MTX)
| If CrCl 30-60 mL/min, reduce dose by 50%
If CrCl < 30 mL/min, do not use |
Mitomycin-C (Mutamycin)
| If CrCl 10-60 mL/min, reduce dose by 25%
If CrCl < 10 mL/min, reduce dose by 50% |
Mitoxantrone (Novantrone)
Nilotinib (Tasigna)
| No dose reduction
Not tested. Not renally excreted (link to the reference)
|
Nilutamide (Nilandron)
| No dose reduction |
Paclitaxel (Taxol)
Pemetrexed (Alimta)
| No dose reduction
If CrCl > 45 mL/min, no dose reduction
If CrCl < 45 mL/min, do not use (link to the reference)
|
Procarbazine (Matulane)
Sorafenib (Nexavar)
| If CrCl < 30 mL/min, do not use
No dose reduction (link to the reference)
|
Streptozocin (Zanosar)
Sunitinib (Sutent)
| If CrCl < 60 mL/min, do not use
If CrCl > 42 mL/min, no dose reduction (link to the reference)
|
Tamoxifen (Nolvadex)
Temsirolimus (Torisel) | No dose reduction No dose reduction (link to the reference)
|
Topotecan (Hycamtin)
| If CrCl > 40 mL/min, no dose reduction
If CrCl 20-39 mL/min, reduce to 0.75 mg/m2 (link to the reference)
|
| UFT | No dose reduction |
Vinblastine (Velban)
| No dose reduction (link to the reference)
|
Vincristine (Oncovin, VCR)
| No dose reduction (link to the reference)
|
Vinorelbine (Navelbine)
| No dose reduction |
