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Cancer of Unknown Primary
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Myelodysplastic Syndrome
Dosage for Hepatic Dysfunction
Dosage for Renal Dysfunction
Calculation of Carboplatin Dose
Dosage for Renal Dysfunction

Alemtuzumab (Campath)

Anastrozole (Arimidex)

Unknown

No dose reduction (link to the reference)
L-Asparaginase (Elspar)
No dose reduction (link to the reference)
Bicalutamide (Casodex)

Bendamustine (Treanda)
No dose reduction (link to the reference)

If CrCl < 40 mL/min, do not use (link to the reference)
Bleomycin (Blenoxane)
If CrCl 10-50 mL/min, reduce dose by 25%
If CrCl < 10 mL/min, reduce dose by 50% (link to the reference)

Bortezomib (Velcade)

Busulfan (Myleran)

No dose reduction (link to the reference)

No dose reduction

Capecitabine (Xeloda)
If CrCl 30-50 mL/min, reduce dose by 25%
If CrCl < 30 mL/min, do not use (link to the reference)
Carboplatin (Paraplatin)
Dosing based on AUC (link to the reference)
Carmustine (BCNU)
If CrCl < 60 mL/min, do not use
Chlorambucil (Leukeran)
No dose reduction
Cisplatin (CDDP)
If CrCl 30-60 mL/min, reduce dose by 50%
If CrCl < 30 mL/min, do not use
Cyclophosphamide (Cytoxan) If CrCl 10-50 mL/min, reduce dose by 25%
If CrCl < 10 mL/min, reduce dose by 50%
Dacarbazine (DTIC)


Dasatinib (Sprycel)

Daunorubicin (Daunomycin)
If CrCL 10-50 mL/min, reduce dose by 25%
If CrCl < 10 mL/min, reduce dose by 50%

Unknown. < 4% excreted by kidney (link to the reference)

If Cr > 3 mg/dL, reduce dose by 50%
Docetaxel (Taxotere) No dose reduction (link to the reference)
Doxorubicin (Adriamycin)
No dose reduction (link to the reference)
Doxil (Pegylated liposomal doxorubicin)

Erlotinib (Tarceva)
No dose reduction (link to the reference)


No dose reduction (link to the reference)
Etoposide (VP-16)
If CrCl 10-50 mL/min, reduce dose by 25%
If CrCl < 10 mL/min, reduce dose by 50%
Exemestane (Aromasin)

Fludarabine (Fludara)


Fluorouracil (5-FU)

Fulvestrant (Faslodex)
No dose reduction (link to the reference)

If CrCl 30-70 mL/min, reduce dose by 20%
If CrCl < 30 mL/min, do not use (link to the reference)

No dose reduction (link to the article)

No dose reduction (link to the reference)
Gemcitabine (Gemzar) No dose reduction (link to the reference)
Goserelin (Zoladex)
No dose reduction (link to the reference)
Hydroxyurea (Hydrea) If CrCl 10-50 mL/min, reduce dose by 50%
If CrCl < 10 mL/min, reduce dose by 80%
Idarubicin (Idamycin)
If CrCl < 10 mL/min, reduce dose by 25% (link to the reference)
Imatinib (Gleevec)
No dose reduction (link to the reference)
Interferon-alpha No dose reduction
Interleukin-2 If Cr > 4-4.5 mg/dL, do not use
Irinotecan (Camptosar, CPT-11)

Ixabepilone (Ixempra)

Lapatinib (Tykerb)

Lenalidomide (Revlimid)


Letrozole (Femara)
No dose reduction (no dose reduction)

If CrCl > 30 mL/min, no dose reduction (link to the reference)

Not studied. Only 2% eliminated by kidneys (link to the reference)

Substantially excreted by kidney. Trials excluded patients with renal insufficiency (link to the reference)

If CrCl > 10 mL/min, no dose reduction (link to the reference)
Leucovorin (LV)
No dose reduction

Lomustine (CCNU)

Melphalan (Alkeran)

If CrCl < 60 mL/min, do not use

PO: if CrCl < 30 mL/min, consider dose reduction (link to the reference)
IV: if BUN > 30 mg/dL, reduce dose by 50%

Methotrexate (MTX)
If CrCl 30-60 mL/min, reduce dose by 50%
If CrCl < 30 mL/min, do not use
Mitomycin-C (Mutamycin)
If CrCl 10-60 mL/min, reduce dose by 25%
If CrCl < 10 mL/min, reduce dose by 50%
Mitoxantrone (Novantrone)

Nilotinib (Tasigna)
No dose reduction

Not tested. Not renally excreted (link to the reference)
Nilutamide (Nilandron)
No dose reduction
Paclitaxel (Taxol)

Pemetrexed (Alimta)
No dose reduction

If CrCl > 45 mL/min, no dose reduction
If CrCl < 45 mL/min, do not use (link to the reference)
Procarbazine (Matulane)

Sorafenib (Nexavar)
If CrCl < 30 mL/min, do not use

No dose reduction (link to the reference)
Streptozocin (Zanosar)

Sunitinib (Sutent)
If CrCl < 60 mL/min, do not use

If CrCl > 42 mL/min, no dose reduction (link to the reference)

Tamoxifen (Nolvadex)

Temsirolimus (Torisel) 

No dose reduction

No dose reduction (link to the reference)

Topotecan (Hycamtin)
If CrCl > 40 mL/min, no dose reduction
If CrCl 20-39 mL/min, reduce to 0.75 mg/m2 (link to the reference)
UFT No dose reduction
Vinblastine (Velban)
No dose reduction (link to the reference)
Vincristine (Oncovin, VCR)
No dose reduction (link to the reference)
Vinorelbine (Navelbine)
No dose reduction